6 generations from a
founding couple with all 'mates' from external randoms
except the cousin pairings
3rd generation cousin pairings 3.7%
4th gen 2.4%
5th gen 1.2%
6th gen 0.4%
Repeated 20 times to produce 20 unrelated 'families'
Then randomly choosing 1 in every 20 to produce the pg0
external profiles to 'marry' into the core family.
Sorted profiles and then checked for >= 5 pairs of
adjascent alleles.
Output file is then checked for single allele matches
and further checked for non sibling matches in
the 11 to 20 digit area.
Before going into Visual Basic Editor go into ordinary
Word and call up anything in the directory you want
the VB files to go into as this is not designated in the
following code.
Using plain text handling Notepad with no line wrap
Copy visual basic code ( between horizontal
black lines ),place between sub () and
end sub,reset and run.
Try code in dnas5.htm before trying this dnas4.htm code
as the 5 simulation is much more straightforward to
understand what is going on and is more compact.
' 20 founding families
' Generating 10 loci x2 profiles
' to be called on later
' 2 +3 +9 +27 +81 +243 = 365 = profiles
' repeated xx (20) times
' the whole routine up to final single allele
' matches repeated tt (20 ) times
' for first run change tt to just 2
zz = 0
Dim ph(20)
Dim ps As String
Dim pg0(365, 20)
' pg8 is 20 founding families from which to select the pg0 file
Dim pg8(20, 1095)
Dim pg1(1, 20)
Dim pg2(2, 20)
' initialising RNG
Randomize
a = 214013
c = 2531011
x0 = Timer
z = 2 ^ 24
Dim pg3(8, 20)
Dim pg4(26, 20)
Dim pg5(80, 20)
Dim pg6(242, 20)
Dim pg7(728, 20)
Open "sept29-7m.txt" For Output As #2
Open "sept29-24" For Output As #24
Open "sept29-25" For Output As #25
Open "sept29-26" For Output As #26
Open "sept29-27" For Output As #27
' change tt limit for overall repeats of routine
For tt = 0 To 19
Open "sept29-28" For Output As #28
' change xx limit here and mid-way down for
' changing < or > the number of founder families
For xx = 0 To 19
count9 = 0
count8 = 0
Open "sept29-0" For Output As #10
Open "sept29-1" For Output As #11
Open "sept29-2" For Output As #12
Open "sept29-3" For Output As #13
Open "sept29-4" For Output As #14
Open "sept29-5" For Output As #15
Open "sept29-6" For Output As #16
Open "sept29-7" For Output As #17
For x = 0 To 364
For j = 0 To 1
' vWA
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.001 Then ph(j) = 11
If ph(j) < 0.106 Then ph(j) = 1
If ph(j) < 0.186 Then ph(j) = 2
If ph(j) < 0.402 Then ph(j) = 3
If ph(j) < 0.672 Then ph(j) = 4
If ph(j) < 0.891 Then ph(j) = 5
If ph(j) < 0.984 Then ph(j) = 6
If ph(j) < 0.998 Then ph(j) = 7
If ph(j) < 1 Then ph(j) = 8
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 2 To 3
' THO1
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.002 Then ph(j) = 11
If ph(j) < 0.243 Then ph(j) = 1
If ph(j) < 0.437 Then ph(j) = 2
If ph(j) < 0.545 Then ph(j) = 3
If ph(j) < 0.546 Then ph(j) = 4
If ph(j) < 0.686 Then ph(j) = 5
If ph(j) < 0.99 Then ph(j) = 6
If ph(j) < 1 Then ph(j) = 7
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 4 To 5
' D8
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.018 Then ph(j) = 11
If ph(j) < 0.031 Then ph(j) = 1
If ph(j) < 0.125 Then ph(j) = 2
If ph(j) < 0.191 Then ph(j) = 3
If ph(j) < 0.334 Then ph(j) = 4
If ph(j) < 0.667 Then ph(j) = 5
If ph(j) < 0.876 Then ph(j) = 6
If ph(j) < 0.964 Then ph(j) = 7
If ph(j) < 0.995 Then ph(j) = 8
If ph(j) < 1 Then ph(j) = 9
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 6 To 7
' FGA
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.025 Then ph(j) = 11
If ph(j) < 0.081 Then ph(j) = 1
If ph(j) < 0.224 Then ph(j) = 2
If ph(j) < 0.411 Then ph(j) = 3
If ph(j) < 0.576 Then ph(j) = 4
If ph(j) < 0.587 Then ph(j) = 5
If ph(j) < 0.726 Then ph(j) = 6
If ph(j) < 0.872 Then ph(j) = 7
If ph(j) < 0.947 Then ph(j) = 8
If ph(j) < 0.982 Then ph(j) = 9
If ph(j) < 1 Then ph(j) = 0
' 1.8% not generated
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 8 To 9
' D21
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.031 Then ph(j) = 11
If ph(j) < 0.191 Then ph(j) = 1
If ph(j) < 0.417 Then ph(j) = 2
If ph(j) < 0.675 Then ph(j) = 3
If ph(j) < 0.702 Then ph(j) = 4
If ph(j) < 0.771 Then ph(j) = 5
If ph(j) < 0.864 Then ph(j) = 6
If ph(j) < 0.882 Then ph(j) = 7
If ph(j) < 0.972 Then ph(j) = 8
If ph(j) < 0.994 Then ph(j) = 9
If ph(j) < 1 Then ph(j) = 0
' 0.5% not generated
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 10 To 11
' D18
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.012 Then ph(j) = 11
If ph(j) < 0.151 Then ph(j) = 1
If ph(j) < 0.276 Then ph(j) = 2
If ph(j) < 0.44 Then ph(j) = 3
If ph(j) < 0.585 Then ph(j) = 4
If ph(j) < 0.722 Then ph(j) = 5
If ph(j) < 0.837 Then ph(j) = 6
If ph(j) < 0.917 Then ph(j) = 7
If ph(j) < 0.958 Then ph(j) = 8
If ph(j) < 0.975 Then ph(j) = 9
If ph(j) < 1 Then ph(j) = 0
' 2.5% not generated
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 12 To 13
' D2S1338
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.037 Then ph(j) = 11
If ph(j) < 0.222 Then ph(j) = 1
If ph(j) < 0.309 Then ph(j) = 2
If ph(j) < 0.419 Then ph(j) = 3
If ph(j) < 0.557 Then ph(j) = 4
If ph(j) < 0.589 Then ph(j) = 5
If ph(j) < 0.613 Then ph(j) = 6
If ph(j) < 0.725 Then ph(j) = 7
If ph(j) < 0.867 Then ph(j) = 8
If ph(j) < 0.978 Then ph(j) = 9
If ph(j) < 1 Then ph(j) = 0
' 2.2% not generated
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 14 To 15
' D16
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.019 Then ph(j) = 11
If ph(j) < 0.148 Then ph(j) = 1
If ph(j) < 0.202 Then ph(j) = 2
If ph(j) < 0.491 Then ph(j) = 3
If ph(j) < 0.779 Then ph(j) = 4
If ph(j) < 0.965 Then ph(j) = 5
If ph(j) < 0.994 Then ph(j) = 6
If ph(j) < 1 Then ph(j) = 7
If ph(j) > 10 Then ph(j) = 0
Next j
For j = 16 To 17
' D19
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.087 Then ph(j) = 11
If ph(j) < 0.309 Then ph(j) = 1
If ph(j) < 0.322 Then ph(j) = 2
If ph(j) < 0.704 Then ph(j) = 3
If ph(j) < 0.713 Then ph(j) = 4
If ph(j) < 0.896 Then ph(j) = 5
If ph(j) < 0.934 Then ph(j) = 6
If ph(j) < 0.975 Then ph(j) = 7
If ph(j) < 0.992 Then ph(j) = 8
If ph(j) < 0.997 Then ph(j) = 9
If ph(j) < 1 Then ph(j) = 0
If ph(j) > 10 Then ph(j) = 0
' 0.3% not generated
Next j
For j = 18 To 19
' D3
' RNG
temp = x0 * a + c
temp = temp / z
x1 = (temp - Fix(temp)) * z
x0 = x1
phj = x1 / z
ph(j) = phj
If ph(j) < 0.001 Then ph(j) = 11
If ph(j) < 0.007 Then ph(j) = 1
If ph(j) < 0.139 Then ph(j) = 2
If ph(j) < 0.404 Then ph(j) = 3
If ph(j) < 0.651 Then ph(j) = 4
If ph(j) < 0.846 Then ph(j) = 5
If ph(j) < 0.987 Then ph(j) = 6
If ph(j) < 1 Then ph(j) = 7
If ph(j) > 10 Then ph(j) = 0
Next j
' directing pairs
For j = 0 To 18 Step 2
If ph(j + 1) < ph(j) Then
jjj = ph(j)
ph(j) = ph(j + 1)
ph(j + 1) = jjj
End If
pg0(x, j) = ph(j)
pg0(x, j + 1) = ph(j + 1)
Next j
Write #10, pg0(x, 0) & pg0(x, 1) & pg0(x, 2) & pg0(x, 3) & pg0(x, 4) & pg0(x, 5) & pg0(x, 6) & pg0(x, 7) & pg0(x, 8) & pg0(x, 9) & pg0(x, 10) & pg0(x, 11) & pg0(x, 12) & pg0(x, 13) & pg0(x, 14) & pg0(x, 15) & pg0(x, 16) & pg0(x, 17) & pg0(x, 18) & pg0(x, 19)
Next x
' founding couple
For m = 0 To 1
For k = 0 To 19
pg1(m, k) = pg0(m, k)
Next k
Write #11, pg1(m, 0) & pg1(m, 1) & pg1(m, 2) & pg1(m, 3) & pg1(m, 4) & pg1(m, 5) & pg1(m, 6) & pg1(m, 7) & pg1(m, 8) & pg1(m, 9) & pg1(m, 10) & pg1(m, 11) & pg1(m, 12) & pg1(m, 13) & pg1(m, 14) & pg1(m, 15) & pg1(m, 16) & pg1(m, 17) & pg1(m, 18) & pg1(m, 19)
Write #28, pg1(m, 0) & pg1(m, 1) & pg1(m, 2) & pg1(m, 3) & pg1(m, 4) & pg1(m, 5) & pg1(m, 6) & pg1(m, 7) & pg1(m, 8) & pg1(m, 9) & pg1(m, 10) & pg1(m, 11) & pg1(m, 12) & pg1(m, 13) & pg1(m, 14) & pg1(m, 15) & pg1(m, 16) & pg1(m, 17) & pg1(m, 18) & pg1(m, 19) & zz & tt & zz & m
Next m
' first generation of 3 offspring
' 4 way random to select one of
' 2 alleles from adam and one of 2 from eve
' 3 times over
For m = 0 To 2
For k = 0 To 18 Step 2
rr = Rnd
pg2(m, k) = pg1(0, k)
pg2(m, k + 1) = pg1(1, k)
If rr < 0.75 Then
pg2(m, k) = pg1(0, k)
pg2(m, k + 1) = pg1(1, k + 1)
End If
If rr < 0.5 Then
pg2(m, k) = pg1(0, k + 1)
pg2(m, k + 1) = pg1(1, k)
End If
If rr < 0.25 Then
pg2(m, k) = pg1(0, k + 1)
pg2(m, k + 1) = pg1(1, k + 1)
End If
Next k
' directing pairs
For j = 0 To 18 Step 2
If pg2(m, j + 1) < pg2(m, j) Then
jjj = pg2(m, j)
pg2(m, j) = pg2(m, j + 1)
pg2(m, j + 1) = jjj
End If
Next j
Write #12, pg2(m, 0) & pg2(m, 1) & pg2(m, 2) & pg2(m, 3) & pg2(m, 4) & pg2(m, 5) & pg2(m, 6) & pg2(m, 7) & pg2(m, 8) & pg2(m, 9) & pg2(m, 10) & pg2(m, 11) & pg2(m, 12) & pg2(m, 13) & pg2(m, 14) & pg2(m, 15) & pg2(m, 16) & pg2(m, 17) & pg2(m, 18) & pg2(m, 19)
Write #28, pg2(m, 0) & pg2(m, 1) & pg2(m, 2) & pg2(m, 3) & pg2(m, 4) & pg2(m, 5) & pg2(m, 6) & pg2(m, 7) & pg2(m, 8) & pg2(m, 9) & pg2(m, 10) & pg2(m, 11) & pg2(m, 12) & pg2(m, 13) & pg2(m, 14) & pg2(m, 15) & pg2(m, 16) & pg2(m, 17) & pg2(m, 18) & pg2(m, 19) & zz & tt & zz & m
Next m
' second generation of 3 offspring of each pg2 parent
' 4 way random to select one of
' 2 alleles from each offsping and
' one of 2 from a random parent
For mm = 0 To 6 Step 3
' mm 1,2 or3 rd child
For m = 0 To 2
' m parent
For k = 0 To 18 Step 2
rr = Rnd
' mm+m+2 (2 as 2 called up previously in pg0)
pg3(mm + m, k) = pg0(m + 2, k)
pg3(mm + m, k + 1) = pg2(m, k)
If rr < 0.75 Then
pg3(mm + m, k) = pg0(m + 2, k)
pg3(mm + m, k + 1) = pg2(m, k + 1)
End If
If rr < 0.5 Then
pg3(mm + m, k) = pg0(m + 2, k + 1)
pg3(mm + m, k + 1) = pg2(m, k)
End If
If rr < 0.25 Then
pg3(mm + m, k) = pg0(m + 2, k + 1)
pg3(mm + m, k + 1) = pg2(m, k + 1)
End If
Next k
' directing pairs
For j = 0 To 18 Step 2
If pg3(mm + m, j + 1) < pg3(mm + m, j) Then
jjj = pg3(mm + m, j)
pg3(mm + m, j) = pg3(mm + m, j + 1)
pg3(mm + m, j + 1) = jjj
End If
Next j
Write #13, pg3(mm + m, 0) & pg3(mm + m, 1) & pg3(mm + m, 2) & pg3(mm + m, 3) & pg3(mm + m, 4) & pg3(mm + m, 5) & pg3(mm + m, 6) & pg3(mm + m, 7) & pg3(mm + m, 8) & pg3(mm + m, 9) & pg3(mm + m, 10) & pg3(mm + m, 11) & pg3(mm + m, 12) & pg3(mm + m, 13) & pg3(mm + m, 14) & pg3(mm + m, 15) & pg3(mm + m, 16) & pg3(mm + m, 17) & pg3(mm + m, 18) & pg3(mm + m, 19)
Write #28, pg3(mm + m, 0) & pg3(mm + m, 1) & pg3(mm + m, 2) & pg3(mm + m, 3) & pg3(mm + m, 4) & pg3(mm + m, 5) & pg3(mm + m, 6) & pg3(mm + m, 7) & pg3(mm + m, 8) & pg3(mm + m, 9) & pg3(mm + m, 10) & pg3(mm + m, 11) & pg3(mm + m, 12) & pg3(mm + m, 13) & pg3(mm + m, 14) & pg3(mm + m, 15) & pg3(mm + m, 16) & pg3(mm + m, 17) & pg3(mm + m, 18) & pg3(mm + m, 19) & zz & tt & zz & mm & zz & m
Next m
Next mm
' third generation of 3 offspring of each pg3 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 18 Step 9
For m = 0 To 8
For k = 0 To 18 Step 2
rr = Rnd
' the + as first 2 + 3used previously
pg4(mm + m, k) = pg0(m + 5, k)
pg4(mm + m, k + 1) = pg3(m, k)
If rr < 0.75 Then
pg4(mm + m, k) = pg0(m + 5, k)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
If rr < 0.5 Then
pg4(mm + m, k) = pg0(m + 5, k + 1)
pg4(mm + m, k + 1) = pg3(m, k)
End If
If rr < 0.25 Then
pg4(mm + m, k) = pg0(m + 5, k + 1)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
Next k
' cousin marriage on 27th mating
rrr = Rnd * 6
If mm + m = 26 Then
Write #24, mm + m, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19)
For k = 0 To 18 Step 2
rr = Rnd
yy = 7
If rrr < 5 Then yy = 6
If rrr < 4 Then yy = 4
If rrr < 3 Then yy = 3
If rrr < 2 Then yy = 1
If rrr < 1 Then yy = 0
pg4(mm + m, k) = pg3(yy, k)
pg4(mm + m, k + 1) = pg3(m, k)
If rr < 0.75 Then
pg4(mm + m, k) = pg3(yy, k)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
If rr < 0.5 Then
pg4(mm + m, k) = pg3(yy, k + 1)
pg4(mm + m, k + 1) = pg3(m, k)
End If
If rr < 0.25 Then
pg4(mm + m, k) = pg3(yy, k + 1)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
Next k
Write #24, mm + m, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg4(mm + m, j + 1) < pg4(mm + m, j) Then
jjj = pg4(mm + m, j)
pg4(mm + m, j) = pg4(mm + m, j + 1)
pg4(mm + m, j + 1) = jjj
End If
Next j
Write #14, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19)
Write #28, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19) & zz & tt & zz & mm & zz & m
Next m
Next mm
' fourth generation of 3 offspring of each pg4 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 54 Step 27
For m = 0 To 26
For k = 0 To 18 Step 2
rr = Rnd
' the +14 as first 2 +3+ 9 used previously
pg5(mm + m, k) = pg0(m + 14, k)
pg5(mm + m, k + 1) = pg4(m, k)
If rr < 0.75 Then
pg5(mm + m, k) = pg0(m + 14, k)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
If rr < 0.5 Then
pg5(mm + m, k) = pg0(m + 14, k + 1)
pg5(mm + m, k + 1) = pg4(m, k)
End If
If rr < 0.25 Then
pg5(mm + m, k) = pg0(m + 14, k + 1)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
Next k
' cousin marriage on 40th mating
rrr1 = Rnd * 6
rrr2 = Rnd * 6
If mm + m = 40 Or mm + m = 80 Then
Write #25, mm + m, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19)
If mm + m = 40 Then rrr = rrr1
If mm + m = 40 Then rrr = rrr2
For k = 0 To 18 Step 2
rr = Rnd
yy = 19
If rrr < 5 Then yy = 25
If rrr < 4 Then yy = 24
If rrr < 3 Then yy = 23
If rrr < 2 Then yy = 21
If rrr < 1 Then yy = 20
pg5(mm + m, k) = pg4(yy, k)
pg5(mm + m, k + 1) = pg4(m, k)
If rr < 0.75 Then
pg5(mm + m, k) = pg4(yy, k)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
If rr < 0.5 Then
pg5(mm + m, k) = pg4(yy, k + 1)
pg5(mm + m, k + 1) = pg4(m, k)
End If
If rr < 0.25 Then
pg5(mm + m, k) = pg4(yy, k + 1)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
Next k
Write #25, mm + m, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg5(mm + m, j + 1) < pg5(mm + m, j) Then
jjj = pg5(mm + m, j)
pg5(mm + m, j) = pg5(mm + m, j + 1)
pg5(mm + m, j + 1) = jjj
End If
Next j
Write #15, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19)
Write #28, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19) & zz & tt & zz & mm & zz & m
Next m
Next mm
' fifth generation of 3 offspring of each pg5 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 162 Step 81
For m = 0 To 80
For k = 0 To 18 Step 2
rr = Rnd
pg6(mm + m, k) = pg0(m + 41, k)
pg6(mm + m, k + 1) = pg5(m, k)
If rr < 0.75 Then
pg6(mm + m, k) = pg0(m + 41, k)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
If rr < 0.5 Then
pg6(mm + m, k) = pg0(m + 41, k + 1)
pg6(mm + m, k + 1) = pg5(m, k)
End If
If rr < 0.25 Then
pg6(mm + m, k) = pg0(m + 41, k + 1)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
Next k
' cousin marriage on 79th mating
rrr = Rnd * 6
If m = 79 Then
Write #26, mm + m, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19)
For k = 0 To 18 Step 2
rr = Rnd
yy = 77
If rrr < 5 Then yy = 75
If rrr < 4 Then yy = 73
If rrr < 3 Then yy = 71
If rrr < 2 Then yy = 69
If rrr < 1 Then yy = 67
pg6(mm + m, k) = pg5(yy, k)
pg6(mm + m, k + 1) = pg5(m, k)
If rr < 0.75 Then
pg6(mm + m, k) = pg5(yy, k)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
If rr < 0.5 Then
pg6(mm + m, k) = pg5(yy, k + 1)
pg6(mm + m, k + 1) = pg5(m, k)
End If
If rr < 0.25 Then
pg6(mm + m, k) = pg5(yy, k + 1)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
Next k
Write #26, mm + m, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg6(mm + m, j + 1) < pg6(mm + m, j) Then
jjj = pg6(mm + m, j)
pg6(mm + m, j) = pg6(mm + m, j + 1)
pg6(mm + m, j + 1) = jjj
End If
Next j
Write #16, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19)
Write #28, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19) & zz & tt & zz & mm & zz & m
' zz is just 0 spacer for the ident numbers at the end of the #28 file and later similar idents
Next m
Next mm
' sixth generation of 3 offspring of each pg6 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 486 Step 243
For m = 0 To 242
For k = 0 To 18 Step 2
rr = Rnd
pg7(mm + m, k) = pg0(m + 122, k)
pg7(mm + m, k + 1) = pg6(m, k)
If rr < 0.75 Then
pg7(mm + m, k) = pg0(m + 122, k)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
If rr < 0.5 Then
pg7(mm + m, k) = pg0(m + 122, k + 1)
pg7(mm + m, k + 1) = pg6(m, k)
End If
If rr < 0.25 Then
pg7(mm + m, k) = pg0(m + 122, k + 1)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
Next k
' cousin marriage on 79th mating
rrr = Rnd * 6
If m = 79 Then
Write #27, mm + m, pg7(mm + m, 0) & pg7(mm + m, 1) & pg7(mm + m, 2) & pg7(mm + m, 3) & pg7(mm + m, 4) & pg7(mm + m, 5) & pg7(mm + m, 6) & pg7(mm + m, 7) & pg7(mm + m, 8) & pg7(mm + m, 9) & pg7(mm + m, 10) & pg7(mm + m, 11) & pg7(mm + m, 12) & pg7(mm + m, 13) & pg7(mm + m, 14) & pg7(mm + m, 15) & pg7(mm + m, 16) & pg7(mm + m, 17) & pg7(mm + m, 18) & pg7(mm + m, 19)
For k = 0 To 18 Step 2
rr = Rnd
yy = 76
If rrr < 5 Then yy = 74
If rrr < 4 Then yy = 72
If rrr < 3 Then yy = 70
If rrr < 2 Then yy = 69
If rrr < 1 Then yy = 68
pg7(mm + m, k) = pg6(yy, k)
pg7(mm + m, k + 1) = pg6(m, k)
If rr < 0.75 Then
pg7(mm + m, k) = pg6(yy, k)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
If rr < 0.5 Then
pg7(mm + m, k) = pg6(yy, k + 1)
pg7(mm + m, k + 1) = pg6(m, k)
End If
If rr < 0.25 Then
pg7(mm + m, k) = pg6(yy, k + 1)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
Next k
Write #27, mm + m, pg7(mm + m, 0) & pg7(mm + m, 1) & pg7(mm + m, 2) & pg7(mm + m, 3) & pg7(mm + m, 4) & pg7(mm + m, 5) & pg7(mm + m, 6) & pg7(mm + m, 7) & pg7(mm + m, 8) & pg7(mm + m, 9) & pg7(mm + m, 10) & pg7(mm + m, 11) & pg7(mm + m, 12) & pg7(mm + m, 13) & pg7(mm + m, 14) & pg7(mm + m, 15) & pg7(mm + m, 16) & pg7(mm + m, 17) & pg7(mm + m, 18) & pg7(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg7(mm + m, j + 1) < pg7(mm + m, j) Then
jjj = pg7(mm + m, j)
pg7(mm + m, j) = pg7(mm + m, j + 1)
pg7(mm + m, j + 1) = jjj
End If
Next j
' adds leading zeros to numbers less than 100
' to structure each number to occupy 3 spaces plus a 0 null spacer/divider
If tt < 10 Then
px = "00" & Trim(Str(tt))
End If
If tt > 9 And tt < 100 Then
px = "0" & Trim(Str(tt))
End If
If tt > 99 Then
px = Trim(Str(tt))
End If
If mm < 10 Then
py = "00" & Trim(Str(mm))
End If
If mm > 9 And mm < 100 Then
py = "0" & Trim(Str(mm))
End If
If mm > 99 Then
py = Trim(Str(mm))
End If
If m < 10 Then
pz = "00" & Trim(Str(m))
End If
If m > 9 And m < 100 Then
pz = "0" & Trim(Str(m))
End If
If m > 99 Then
pz = Trim(Str(m))
End If
Write #17, pg7(mm + m, 0) & pg7(mm + m, 1) & pg7(mm + m, 2) & pg7(mm + m, 3) & pg7(mm + m, 4) & pg7(mm + m, 5) & pg7(mm + m, 6) & pg7(mm + m, 7) & pg7(mm + m, 8) & pg7(mm + m, 9) & pg7(mm + m, 10) & pg7(mm + m, 11) & pg7(mm + m, 12) & pg7(mm + m, 13) & pg7(mm + m, 14) & pg7(mm + m, 15) & pg7(mm + m, 16) & pg7(mm + m, 17) & pg7(mm + m, 18) & pg7(mm + m, 19) & zz & px & zz & py & zz & pz
Next m
Next mm
Close #10
Close #11
Close #12
Close #13
Close #14
Close #15
Close #16
Close #17
Next xx
Close #24
Close #25
Close #26
Close #27
Close #28
' randomly selects one of 20 for the pg0 file
' of external 'mates'
Open "sept29-28" For Input As #28
' change the limit 19 below and the 20
' in the rpg variable below to match
' the xx limit at the beginning for < or > than 20 founding families
For xx = 0 To 19
For mm = 0 To 364
Input #28, pg8(xx, mm)
Next mm
Next xx
Close #28
Open "sept29-29" For Output As #29
For mm = 0 To 364
rpg = Int(Rnd * 20)
pgd = pg8(rpg, mm)
Write #29, pgd
For k = 1 To 20
pg0(mm, k) = Mid(pgd, k, 1)
Next k
Next mm
Close #29
' core family generated using external input from 20 families
Open "sept29-24" For Output As #24
Open "sept29-25" For Output As #25
Open "sept29-26" For Output As #26
Open "sept29-27" For Output As #27
count9 = 0
count8 = 0
Open "sept29-0" For Output As #10
Open "sept29-1" For Output As #11
Open "sept29-2" For Output As #12
Open "sept29-3" For Output As #13
Open "sept29-4" For Output As #14
Open "sept29-5" For Output As #15
Open "sept29-6" For Output As #16
Open "sept29-7" For Output As #17
' generating adam and eve
For m = 0 To 1
For k = 0 To 19
pg1(m, k) = pg0(m, k)
Next k
Write #11, pg1(m, 0) & pg1(m, 1) & pg1(m, 2) & pg1(m, 3) & pg1(m, 4) & pg1(m, 5) & pg1(m, 6) & pg1(m, 7) & pg1(m, 8) & pg1(m, 9) & pg1(m, 10) & pg1(m, 11) & pg1(m, 12) & pg1(m, 13) & pg1(m, 14) & pg1(m, 15) & pg1(m, 16) & pg1(m, 17) & pg1(m, 18) & pg1(m, 19)
Next m
' first generation of 3 offspring
' 4 way random to select one of
' 2 alleles from adam and one of 2 from eve
' 3 times over
For m = 0 To 2
For k = 0 To 18 Step 2
rr = Rnd
pg2(m, k) = pg1(0, k)
pg2(m, k + 1) = pg1(1, k)
If rr < 0.75 Then
pg2(m, k) = pg1(0, k)
pg2(m, k + 1) = pg1(1, k + 1)
End If
If rr < 0.5 Then
pg2(m, k) = pg1(0, k + 1)
pg2(m, k + 1) = pg1(1, k)
End If
If rr < 0.25 Then
pg2(m, k) = pg1(0, k + 1)
pg2(m, k + 1) = pg1(1, k + 1)
End If
Next k
' directing pairs
For j = 0 To 18 Step 2
If pg2(m, j + 1) < pg2(m, j) Then
jjj = pg2(m, j)
pg2(m, j) = pg2(m, j + 1)
pg2(m, j + 1) = jjj
End If
Next j
Write #12, pg2(m, 0) & pg2(m, 1) & pg2(m, 2) & pg2(m, 3) & pg2(m, 4) & pg2(m, 5) & pg2(m, 6) & pg2(m, 7) & pg2(m, 8) & pg2(m, 9) & pg2(m, 10) & pg2(m, 11) & pg2(m, 12) & pg2(m, 13) & pg2(m, 14) & pg2(m, 15) & pg2(m, 16) & pg2(m, 17) & pg2(m, 18) & pg2(m, 19)
Next m
' second generation of 3 offspring of each pg2 parent
' 4 way random to select one of
' 2 alleles from each offsping and
' one of 2 from a random parent
For mm = 0 To 6 Step 3
' mm 1,2 or3 rd child
For m = 0 To 2
' m parent
For k = 0 To 18 Step 2
rr = Rnd
' mm+m+2 (2 as 2 called up previously in pg0)
pg3(mm + m, k) = pg0(m + 2, k)
pg3(mm + m, k + 1) = pg2(m, k)
If rr < 0.75 Then
pg3(mm + m, k) = pg0(m + 2, k)
pg3(mm + m, k + 1) = pg2(m, k + 1)
End If
If rr < 0.5 Then
pg3(mm + m, k) = pg0(m + 2, k + 1)
pg3(mm + m, k + 1) = pg2(m, k)
End If
If rr < 0.25 Then
pg3(mm + m, k) = pg0(m + 2, k + 1)
pg3(mm + m, k + 1) = pg2(m, k + 1)
End If
Next k
' directing pairs
For j = 0 To 18 Step 2
If pg3(mm + m, j + 1) < pg3(mm + m, j) Then
jjj = pg3(mm + m, j)
pg3(mm + m, j) = pg3(mm + m, j + 1)
pg3(mm + m, j + 1) = jjj
End If
Next j
Write #13, pg3(mm + m, 0) & pg3(mm + m, 1) & pg3(mm + m, 2) & pg3(mm + m, 3) & pg3(mm + m, 4) & pg3(mm + m, 5) & pg3(mm + m, 6) & pg3(mm + m, 7) & pg3(mm + m, 8) & pg3(mm + m, 9) & pg3(mm + m, 10) & pg3(mm + m, 11) & pg3(mm + m, 12) & pg3(mm + m, 13) & pg3(mm + m, 14) & pg3(mm + m, 15) & pg3(mm + m, 16) & pg3(mm + m, 17) & pg3(mm + m, 18) & pg3(mm + m, 19)
Next m
Next mm
' third generation of 3 offspring of each pg3 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 18 Step 9
For m = 0 To 8
For k = 0 To 18 Step 2
rr = Rnd
' the + as first 2 + 3used previously
pg4(mm + m, k) = pg0(m + 5, k)
pg4(mm + m, k + 1) = pg3(m, k)
If rr < 0.75 Then
pg4(mm + m, k) = pg0(m + 5, k)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
If rr < 0.5 Then
pg4(mm + m, k) = pg0(m + 5, k + 1)
pg4(mm + m, k + 1) = pg3(m, k)
End If
If rr < 0.25 Then
pg4(mm + m, k) = pg0(m + 5, k + 1)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
Next k
' cousin marriage on 27th mating
rrr = Rnd * 6
If mm + m = 26 Then
Write #24, mm + m, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19)
For k = 0 To 18 Step 2
rr = Rnd
yy = 7
If rrr < 5 Then yy = 6
If rrr < 4 Then yy = 4
If rrr < 3 Then yy = 3
If rrr < 2 Then yy = 1
If rrr < 1 Then yy = 0
pg4(mm + m, k) = pg3(yy, k)
pg4(mm + m, k + 1) = pg3(m, k)
If rr < 0.75 Then
pg4(mm + m, k) = pg3(yy, k)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
If rr < 0.5 Then
pg4(mm + m, k) = pg3(yy, k + 1)
pg4(mm + m, k + 1) = pg3(m, k)
End If
If rr < 0.25 Then
pg4(mm + m, k) = pg3(yy, k + 1)
pg4(mm + m, k + 1) = pg3(m, k + 1)
End If
Next k
Write #24, mm + m, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg4(mm + m, j + 1) < pg4(mm + m, j) Then
jjj = pg4(mm + m, j)
pg4(mm + m, j) = pg4(mm + m, j + 1)
pg4(mm + m, j + 1) = jjj
End If
Next j
Write #14, pg4(mm + m, 0) & pg4(mm + m, 1) & pg4(mm + m, 2) & pg4(mm + m, 3) & pg4(mm + m, 4) & pg4(mm + m, 5) & pg4(mm + m, 6) & pg4(mm + m, 7) & pg4(mm + m, 8) & pg4(mm + m, 9) & pg4(mm + m, 10) & pg4(mm + m, 11) & pg4(mm + m, 12) & pg4(mm + m, 13) & pg4(mm + m, 14) & pg4(mm + m, 15) & pg4(mm + m, 16) & pg4(mm + m, 17) & pg4(mm + m, 18) & pg4(mm + m, 19)
Next m
Next mm
' fourth generation of 3 offspring of each pg4 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 54 Step 27
For m = 0 To 26
For k = 0 To 18 Step 2
rr = Rnd
' the +14 as first 2 +3+ 9 used previously
pg5(mm + m, k) = pg0(m + 14, k)
pg5(mm + m, k + 1) = pg4(m, k)
If rr < 0.75 Then
pg5(mm + m, k) = pg0(m + 14, k)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
If rr < 0.5 Then
pg5(mm + m, k) = pg0(m + 14, k + 1)
pg5(mm + m, k + 1) = pg4(m, k)
End If
If rr < 0.25 Then
pg5(mm + m, k) = pg0(m + 14, k + 1)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
Next k
' cousin marriage on 40th mating
rrr1 = Rnd * 6
rrr2 = Rnd * 6
If mm + m = 40 Or mm + m = 80 Then
Write #25, mm + m, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19)
If mm + m = 40 Then rrr = rrr1
If mm + m = 40 Then rrr = rrr2
For k = 0 To 18 Step 2
rr = Rnd
yy = 19
If rrr < 5 Then yy = 25
If rrr < 4 Then yy = 24
If rrr < 3 Then yy = 23
If rrr < 2 Then yy = 21
If rrr < 1 Then yy = 20
pg5(mm + m, k) = pg4(yy, k)
pg5(mm + m, k + 1) = pg4(m, k)
If rr < 0.75 Then
pg5(mm + m, k) = pg4(yy, k)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
If rr < 0.5 Then
pg5(mm + m, k) = pg4(yy, k + 1)
pg5(mm + m, k + 1) = pg4(m, k)
End If
If rr < 0.25 Then
pg5(mm + m, k) = pg4(yy, k + 1)
pg5(mm + m, k + 1) = pg4(m, k + 1)
End If
Next k
Write #25, mm + m, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg5(mm + m, j + 1) < pg5(mm + m, j) Then
jjj = pg5(mm + m, j)
pg5(mm + m, j) = pg5(mm + m, j + 1)
pg5(mm + m, j + 1) = jjj
End If
Next j
Write #15, pg5(mm + m, 0) & pg5(mm + m, 1) & pg5(mm + m, 2) & pg5(mm + m, 3) & pg5(mm + m, 4) & pg5(mm + m, 5) & pg5(mm + m, 6) & pg5(mm + m, 7) & pg5(mm + m, 8) & pg5(mm + m, 9) & pg5(mm + m, 10) & pg5(mm + m, 11) & pg5(mm + m, 12) & pg5(mm + m, 13) & pg5(mm + m, 14) & pg5(mm + m, 15) & pg5(mm + m, 16) & pg5(mm + m, 17) & pg5(mm + m, 18) & pg5(mm + m, 19)
Next m
Next mm
' fifth generation of 3 offspring of each pg5 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 162 Step 81
For m = 0 To 80
For k = 0 To 18 Step 2
rr = Rnd
pg6(mm + m, k) = pg0(m + 41, k)
pg6(mm + m, k + 1) = pg5(m, k)
If rr < 0.75 Then
pg6(mm + m, k) = pg0(m + 41, k)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
If rr < 0.5 Then
pg6(mm + m, k) = pg0(m + 41, k + 1)
pg6(mm + m, k + 1) = pg5(m, k)
End If
If rr < 0.25 Then
pg6(mm + m, k) = pg0(m + 41, k + 1)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
Next k
' cousin marriage on 79th mating
rrr = Rnd * 6
If m = 79 Then
Write #26, mm + m, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19)
For k = 0 To 18 Step 2
rr = Rnd
yy = 77
If rrr < 5 Then yy = 75
If rrr < 4 Then yy = 73
If rrr < 3 Then yy = 71
If rrr < 2 Then yy = 69
If rrr < 1 Then yy = 67
pg6(mm + m, k) = pg5(yy, k)
pg6(mm + m, k + 1) = pg5(m, k)
If rr < 0.75 Then
pg6(mm + m, k) = pg5(yy, k)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
If rr < 0.5 Then
pg6(mm + m, k) = pg5(yy, k + 1)
pg6(mm + m, k + 1) = pg5(m, k)
End If
If rr < 0.25 Then
pg6(mm + m, k) = pg5(yy, k + 1)
pg6(mm + m, k + 1) = pg5(m, k + 1)
End If
Next k
Write #26, mm + m, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg6(mm + m, j + 1) < pg6(mm + m, j) Then
jjj = pg6(mm + m, j)
pg6(mm + m, j) = pg6(mm + m, j + 1)
pg6(mm + m, j + 1) = jjj
End If
Next j
Write #16, pg6(mm + m, 0) & pg6(mm + m, 1) & pg6(mm + m, 2) & pg6(mm + m, 3) & pg6(mm + m, 4) & pg6(mm + m, 5) & pg6(mm + m, 6) & pg6(mm + m, 7) & pg6(mm + m, 8) & pg6(mm + m, 9) & pg6(mm + m, 10) & pg6(mm + m, 11) & pg6(mm + m, 12) & pg6(mm + m, 13) & pg6(mm + m, 14) & pg6(mm + m, 15) & pg6(mm + m, 16) & pg6(mm + m, 17) & pg6(mm + m, 18) & pg6(mm + m, 19)
Next m
Next mm
' sixth generation of 3 offspring of each pg6 parent
' 4 way random to select one of
' 2 alleles from each parent and
' 2 from a random parent
For mm = 0 To 486 Step 243
For m = 0 To 242
For k = 0 To 18 Step 2
rr = Rnd
pg7(mm + m, k) = pg0(m + 122, k)
pg7(mm + m, k + 1) = pg6(m, k)
If rr < 0.75 Then
pg7(mm + m, k) = pg0(m + 122, k)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
If rr < 0.5 Then
pg7(mm + m, k) = pg0(m + 122, k + 1)
pg7(mm + m, k + 1) = pg6(m, k)
End If
If rr < 0.25 Then
pg7(mm + m, k) = pg0(m + 122, k + 1)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
Next k
' cousin marriage on 79th mating
rrr = Rnd * 6
If m = 79 Then
Write #27, mm + m, pg7(mm + m, 0) & pg7(mm + m, 1) & pg7(mm + m, 2) & pg7(mm + m, 3) & pg7(mm + m, 4) & pg7(mm + m, 5) & pg7(mm + m, 6) & pg7(mm + m, 7) & pg7(mm + m, 8) & pg7(mm + m, 9) & pg7(mm + m, 10) & pg7(mm + m, 11) & pg7(mm + m, 12) & pg7(mm + m, 13) & pg7(mm + m, 14) & pg7(mm + m, 15) & pg7(mm + m, 16) & pg7(mm + m, 17) & pg7(mm + m, 18) & pg7(mm + m, 19)
For k = 0 To 18 Step 2
rr = Rnd
yy = 76
If rrr < 5 Then yy = 74
If rrr < 4 Then yy = 72
If rrr < 3 Then yy = 70
If rrr < 2 Then yy = 69
If rrr < 1 Then yy = 68
pg7(mm + m, k) = pg6(yy, k)
pg7(mm + m, k + 1) = pg6(m, k)
If rr < 0.75 Then
pg7(mm + m, k) = pg6(yy, k)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
If rr < 0.5 Then
pg7(mm + m, k) = pg6(yy, k + 1)
pg7(mm + m, k + 1) = pg6(m, k)
End If
If rr < 0.25 Then
pg7(mm + m, k) = pg6(yy, k + 1)
pg7(mm + m, k + 1) = pg6(m, k + 1)
End If
Next k
Write #27, mm + m, pg7(mm + m, 0) & pg7(mm + m, 1) & pg7(mm + m, 2) & pg7(mm + m, 3) & pg7(mm + m, 4) & pg7(mm + m, 5) & pg7(mm + m, 6) & pg7(mm + m, 7) & pg7(mm + m, 8) & pg7(mm + m, 9) & pg7(mm + m, 10) & pg7(mm + m, 11) & pg7(mm + m, 12) & pg7(mm + m, 13) & pg7(mm + m, 14) & pg7(mm + m, 15) & pg7(mm + m, 16) & pg7(mm + m, 17) & pg7(mm + m, 18) & pg7(mm + m, 19)
End If
' directing pairs
For j = 0 To 18 Step 2
If pg7(mm + m, j + 1) < pg7(mm + m, j) Then
jjj = pg7(mm + m, j)
pg7(mm + m, j) = pg7(mm + m, j + 1)
pg7(mm + m, j + 1) = jjj
End If
Next j
' adds leading zeros to numbers less than 100
If tt < 10 Then
px = "00" & Trim(Str(tt))
End If
If tt > 9 And tt < 100 Then
px = "0" & Trim(Str(tt))
End If
If tt > 99 Then
px = Trim(Str(tt))
End If
If mm < 10 Then
py = "00" & Trim(Str(mm))
End If
If mm > 9 And mm < 100 Then
py = "0" & Trim(Str(mm))
End If
If mm > 99 Then
py = Trim(Str(mm))
End If
If m < 10 Then
pz = "00" & Trim(Str(m))
End If
If m > 9 And m < 100 Then
pz = "0" & Trim(Str(m))
End If
If m > 99 Then
pz = Trim(Str(m))
End If
' ident added at the end of #17 file
Write #17, pg7(mm + m, 0) & pg7(mm + m, 1) & pg7(mm + m, 2) & pg7(mm + m, 3) & pg7(mm + m, 4) & pg7(mm + m, 5) & pg7(mm + m, 6) & pg7(mm + m, 7) & pg7(mm + m, 8) & pg7(mm + m, 9) & pg7(mm + m, 10) & pg7(mm + m, 11) & pg7(mm + m, 12) & pg7(mm + m, 13) & pg7(mm + m, 14) & pg7(mm + m, 15) & pg7(mm + m, 16) & pg7(mm + m, 17) & pg7(mm + m, 18) & pg7(mm + m, 19) & zz & px & zz & py & zz & pz
Next m
Next mm
Close #10
Close #11
Close #12
Close #13
Close #14
Close #15
Close #16
Close #17
' sort contents of file sept29-7
Documents.Open FileName:="sept29-7", ConfirmConversions:=False, ReadOnly:= _
False, AddToRecentFiles:=False, PasswordDocument:="", PasswordTemplate:= _
"", Revert:=False, WritePasswordDocument:="", WritePasswordTemplate:="", _
Format:=wdOpenFormatAuto
Selection.Sort ExcludeHeader:=False, FieldNumber:="Paragraphs", _
SortFieldType:=wdSortFieldAlphanumeric, SortOrder:=wdSortOrderAscending, _
FieldNumber2:="", SortFieldType2:=wdSortFieldAlphanumeric, SortOrder2:= _
wdSortOrderAscending, FieldNumber3:="", SortFieldType3:= _
wdSortFieldAlphanumeric, SortOrder3:=wdSortOrderAscending, Separator:= _
wdSortSeparateByTabs, SortColumn:=False, CaseSensitive:=False, LanguageID _
:=wdLanguageNone
ActiveDocument.SaveAs FileName:="sept29-7.txt", FileFormat:=wdFormatText, _
LockComments:=False, Password:="", AddToRecentFiles:=True, WritePassword _
:="", ReadOnlyRecommended:=False, EmbedTrueTypeFonts:=False, _
SaveNativePictureFormat:=False, SaveFormsData:=False, SaveAsAOCELetter:= _
False
ActiveWindow.Close
' Find matching pairs in 10 digits
' xxxx is count =
xxxx = 729
bb$ = "0"
count1 = 0
Open "sept29-7.txt" For Input As #1
' for 10 matches
xxxx = xxxx - 1
For x = 0 To xxxx
Input #1, ps
aa$ = Left(ps, 10)
If aa$ = bb$ Then
Write #2, ps, pps
count1 = count1 + 1
End If
bb$ = aa$
pps = ps
Next x
' most write statements following are disabled
If count1 > 0 Then
' Write #2, xx, count1
End If
Close #1
Open "sept29-7.txt" For Input As #1
' Find matching pairs in 12 digits
bb$ = "0"
count2 = 0
For x = 0 To xxxx
Input #1, ps
aa$ = Left(ps, 12)
If aa$ = bb$ Then
' Write #2, "twelve", ps, pps
count2 = count2 + 1
End If
bb$ = aa$
pps = ps
Next x
If count2 > 0 Then
' Write #2, xx, count2
End If
Close #1
Open "sept29-7.txt" For Input As #1
' Find matching pairs in 14 digits
bb$ = "0"
count3 = 0
For x = 0 To xxxx
Input #1, ps
aa$ = Left(ps, 14)
If aa$ = bb$ Then
' Write #2, ps
count3 = count3 + 1
End If
bb$ = aa$
Next x
If count3 > 0 Then
' Write #2, xx, count3
End If
Close #1
Open "sept29-7.txt" For Input As #1
' Find matching pairs in 16 digits
bb$ = "0"
count4 = 0
For x = 0 To xxxx
Input #1, ps
aa$ = Left(ps, 16)
If aa$ = bb$ Then
' Write #2, ps
count4 = count4 + 1
End If
bb$ = aa$
Next x
If count4 > 0 Then
' Write #2, xx, count4
End If
Close #1
Open "sept29-7.txt" For Input As #1
' Find matching pairs in 18 digits
bb$ = "0"
count5 = 0
For x = 0 To xxxx
Input #1, ps
aa$ = Left(ps, 6)
If aa$ = bb$ Then
' Write #2, ps
count5 = count5 + 1
End If
bb$ = aa$
Next x
If count5 > 0 Then
' Write #2, xx, count5
End If
Close #1
Open "sept29-7.txt" For Input As #1
' Find matching pairs in 20 digits
bb$ = "0"
count6 = 0
For x = 0 To xxxx
Input #1, ps
aa$ = Left(ps, 8)
If aa$ = bb$ Then
' Write #2, ps
count6 = count6 + 1
End If
bb$ = aa$
Next x
If count6 > 0 Then
' Write #2, xx, count6
End If
count1t = count1t + count1
count2t = count2t + count2
count3t = count3t + count3
count4t = count4t + count4
count5t = count5t + count5
count6t = count6t + count6
Close #1
Next tt
Write #2, count1t, count2t, count3t, count4t,count5t, count6t
Close #2
Close #24
Close #25
Close #26
' counts of matches of single alleles over 10
Dim ca(20)
Dim da(20)
Dim ct(1000)
Dim pt As String
xxxx = count1t
count1 = 0
count2 = 0
count3 = 0
count4 = 0
count5 = 0
count6 = 0
count7 = 0
count8 = 0
count9 = 0
count10 = 0
Open "sept29-7m.txt" For Input As #1
Open "sept29-7r.txt" For Output As #2
For x = 1 To xxxx
Input #1, ps, pt
For j = 11 To 20
ca(j) = Mid(ps, j, 1)
da(j) = Mid(pt, j, 1)
Next j
' figures at end of profiles are tt,mm and m - if m the same ,then siblings
' last 11 digits are idents
e = Right(ps, 11)
f = Right(pt, 11)
' last 3 digits are the same if siblings
e2 = Right(ps, 3)
f2 = Right(pt, 3)
Count = 0
For j = 11 To 19 Step 2
flag = 0
If ca(j) = da(j) Or ca(j) = da(j + 1) Then
Count = Count + 1
flag = flag + 1
End If
If ca(j + 1) = da(j) Or ca(j + 1) = da(j + 1) Then
Count = Count + 1
flag = flag + 1
' dis-counting false additions concerning unfounded repeats
End If
If ca(j) = ca(j + 1) And da(j) <> da(j + 1) And flag = 2 Then Count = Count - 1
Next j
If Count = 1 Then count1 = count1 + 1
If Count = 2 Then count2 = count2 + 1
If Count = 3 Then count3 = count3 + 1
If Count = 4 Then count4 = count4 + 1
If Count = 5 Then count5 = count5 + 1
If Count = 6 Then count6 = count6 + 1
If Count = 7 Then count7 = count7 + 1
If Count = 8 Then count8 = count8 + 1
If Count = 9 Then count9 = count9 + 1
If Count = 10 Then count10 = count10 + 1
' count for first ten only match not recorded
' no diference in match data for adjascent lines of results
' differences only for 11 to 20 matches between suceeding lines
Write #2, count1, count2, count3, count4, count5, count6, count7, count8, count9, count10, e, f
If e2 <> f2 Then
Write #2, " ** non-sib match ** ", e2, f2
End If
Next x
Close #1
Close #2
